The plaque build-up also increases your risk of cardiovascular disease, heart attack, stroke, and other health problems. This leads to a build-up of plaque on the walls of your arteries, which can narrow them and make it difficult for blood to flow through. When you have high cholesterol, it means there’s too much low-density lipoprotein (LDL) cholesterol (the “bad” cholesterol) in your blood. RELATED: Statins: Uses, common brands, and safety info How do statins work? Read on to learn more about how statins work, their interaction with grapefruit, and what you can do to avoid problems. If you’re taking a statin to help lower your cholesterol levels, it’s important to understand the potential grapefruit interaction. This causes an increase in the levels of statins in the blood, which can increase the risk of side effects, most notably muscle problems. Grapefruit contains a chemical called furanocoumarin, which inhibits the enzyme that breaks down statins. While effective, one potential downside to statin drugs is their ability to interact with grapefruit. Statins are some of the most prescribed drugs in the United States, and they’re generally considered safe and effective. They work by inhibiting the enzyme in the liver responsible for making cholesterol, known as HMG-CoA reductase. Statins are a class of drugs used to lower cholesterol levels. How do statins work? | What happens if you eat grapefruit while on statins? | Which statins are safe with grapefruit? | Can I eat grapefruit in the morning and take Lipitor at night? | Other grapefruit-drug interactions Share on Facebook Facebook Logo Share on Twitter Twitter Logo Share on LinkedIn LinkedIn Logo Copy URL to clipboard Share Icon URL copied to clipboard
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